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Polypharmacy is used increasingly in the treatment of depression. In augmentation treatment, the second agent does not work alone but may potentiate the antidepressant, used in 38% of combinations, followed by mirtazapine in 19%. . up to 20% of treatment resistance can be attributed to poor treatment compliance.

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Keywords: Unipolar depression, mirtazapine, lithium, carbamazepine, . Treatment resistant depression (TRD) before entering the study was defined as failure

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M, 2003. Lithium augmentation in treatment-resistant depression: clinical evidence, serotonergic and endo- crine mechanisms. Pharmacopsychiatry 36 Suppl 3,

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Outcomes in Depressed Outpatients Requiring One or Several Treatment .. Bauer M, Dopfmer S. Lithium augmentation in treatment-resistant depression: meta- Hannan N, Hamzah Z, Akinpeloye HO, Meagher D. Venlafaxine- mirtazapine

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D evelop evidence-based strategies to combine and augment pharmacologic regimens in patients with treatment-resistant depression. • R ecognize the

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Augmentation therapy works by improving on the intended neurotransmis- sion of the Abstract. Treatment-resistant depression, or difficult-to-treat depression is emerging as a focus of . and norepinephrine, and mirtazapine acts on NE and

Atypical antidepressants effectively augment therapy in major depressive These agents include bupropion (Wellbutrin), mirtazapine (Remeron), and . Assessment of patients with treatment-resistant depression should

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Treatment-resistant depression (TRD)—depression that does not remit after one or more adequately include augmentation strategies, switching agents, combining .. mirtazapine and nortriptyline following two consecutive failed medication

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There are three basic approaches for treatment-resistant depression: medications, Celexa, and Zoloft -- as well as drugs from other classes, like Effexor, Cymbalta, Wellbutrin, and Remeron. This is called add-on or augmentation therapy.

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Many people being treated for depression do not experience relief from Initial research found that mirtazapine augmentation of an SSRI was better at quetiapine (Seroquel), and — for treatment-resistant depression — an


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