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In 2003, Vioxx, Celebrex, and Bextra reaped more than $6 billion in sales, driven by $400 million in Are there natural alternatives that work? In 2003, Public Citizen issued a safety alert about all NSAIDs including the COX-2 inhibitors:
The situation with Celebrex is different than the situation with Vioxx. Alternatives to celecoxib should be considered, based on individual patient needs and risk factors. "FDA Alert for Practitioners on Celebrex (celecoxib).
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